Real-World Impact

How QurieGen's High-Resolution Cellular Mapping, Derisk R&D, Save Time, and Unlock Novel Biology

QurieGen transforms drug development from an extreme risk problem into an engineering solution. Explore how leading pharmaceutical companies use our platform to gain high-resolution, quantitative insights, accelerate their pipelines up to four times faster, and avoid costly late-stage failures.

4X

Biomarker Discovery

Faster R&D Execution

Identifying novel biomarkers for patient stratification.

10×

Mechanism of Action

More mechanistic insights

Elucidating complex drug interactions at single-cell resolution.

Virtual Screening

Saving costs and time

Simulating drug efficacy before wet-lab testing.

Our Workflow

We partner with you end-to-end - from experimental design through biological insight and we take on projects that don’t come with a manual.

01

Project design

  • We start by working side-by-side with you to shape studies around your real scientific questions.
  • Our proprietary single-cell platform is configured specifically for each project—no templates, no black boxes.
  • Need scale? We design large, bespoke antibody panels (350+ antibodies) in-house to match your biology, not the other way around.
Cell Workflow
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Deep Dive Case Studies

Explore how our partners are using QuRIE-seq to solve critical R&D challenges.

Mode of Action of Ibrutinib: Combination Therapy Opportunity
New Combo Therapy

Mode of Action of Ibrutinib: Combination Therapy Opportunity

Identifying signal transduction leakage and new combination therapy opportunities.

Key Results
MoA Elucidation
Aduro Biotech (Chinook) Logo

Partner

Aduro Biotech (Chinook)

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Case Study Details

The Problem

Aduro Biotech, now part of Chinook Therapeutics, is a clinical-stage biopharmaceutical company that focuses on developing immunotherapeutics. Aduro Biotech needed to fully understand the Mode of Action (MoA) of Ibrutinib, a B-cell cancer treatment (FDA-approved), to identify any signal leakage or potential areas for improvement.

QurieGen Solution

We utilised QuRIE-seq single-cell technology on BJAB cells to capture the temporal dynamics of changes in phosphoproteins and mRNA following Ibrutinib treatment.

Scientific Impact

Analysis revealed signal transduction leakage. We found that Ibrutinib only partially blocks B-cell signal transduction...

Business Impact

The identification of a new combination therapy opportunity.

Deep Characterisation of Antibody Secreting Cells (ASCs)
4x Faster

Deep Characterisation of Antibody Secreting Cells (ASCs)

Deep profiling of ASC subclasses to map variations in signalling pathways.

Key Results
10x Insights
Acerta Pharma (AstraZeneca) Logo

Partner

Acerta Pharma (AstraZeneca)

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Case Study Details

The Problem

Acerta Pharma... sought to understand the biochemical differences among various Ig-secreting cell subclasses.

QurieGen Solution

Using an in vitro method to differentiate peripheral B-cells into ASCs, we employed QuRIE-seq...

Scientific Impact

This resulted in the first in-depth characterisation of ASCs, providing 10 times more insights...

Business Impact

The approach was 4 times faster than traditional R&D methods.

Biochemical Profiling of PBMC
4x Faster

Biochemical Profiling of PBMC

High-resolution mapping of cellular response to a TLR7 agonist in heterogeneous populations.

Key Results
High-Res Mapping
Janssen Pharmaceuticals Logo

Partner

Janssen Pharmaceuticals

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Case Study Details

The Problem

Janssen Pharmaceuticals... required high-resolution mapping of the cellular response to a drug candidate.

QurieGen Solution

We applied QuRIE-seq to analyse the entire population of peripheral blood mononuclear cells (PBMCs).

Scientific Impact

Treatment with the agonist showed time-dependent, cell-subtype-specific changes across both the transcriptome and proteome landscapes.

Business Impact

The analysis was completed 4 times faster than conventional methods.